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Use of time from fever onset improves the diagnostic accuracy of C-reactive protein in identifying bacterial infections
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  • Published on:
    Re: Using time and serial measurements to improve diagnostic strategies in febrile children
    • Maskit Bar-Meir, Dr
    • Other Contributors:
      • Idan Segal, Matityahu Ehrlichman and Joseph Urbach

    We thank Dr. Nijman et al. for their thoughtful comments, and agree with their observations.

    Our study, as well as their work , highlight the need to take fever duration into account when interpreting CRP results in febrile children. Future longitudinal studies ,enrolling large numbers of subjects, may focus on generating "CRP curves" , similar to those used for example in interpreting bilirubin levels in neon...

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    Conflict of Interest:
    None declared.
  • Published on:
    Using time and serial measurements to improve diagnostic strategies in febrile children
    • Ruud G. Nijman, research fellow, paediatric specialty trainee
    • Other Contributors:
      • Rianne Oostenbrink

    Response to: 1 Segal I, Ehrlichman M, Urbach J, Bar-Meir M. Use of time from fever onset improves the diagnostic accuracy of C-reactive protein in identifying bacterial infections. Arch Dis Child. Nov 2014;99(11):974-978.

    We thank Segal et al. for their work and congratulate them with this interesting paper. The diagnostic value of CRP as reported by Segal et al. is very much in line with earlier work, and in ke...

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    Conflict of Interest:
    None declared.