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When two trials conflict: bronchiolitis and hypertonic saline

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The editors of JAMA Pediatrics must have been flummoxed when they received two papers at the same time describing the same interventional trial, with completely different results. Both were trials comparing 3% with 0.9% nebulised saline in bronchiolitis, and both were conducted in the emergency departments (EDs) of US children's hospitals. The editors took the brave decision to publish them simultaneously with an accompanying editorial.

Both trials recruited infants under two years presenting to ED with a first episode of clinically diagnosed bronchiolitis, and …

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  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.