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Question 1
Do feeding practices during transfusion influence the risk of developing necrotising enterocolitis in preterm infants?
  1. Amy K Keir1,
  2. Dominic Wilkinson2,3,4
  1. 1Division of Neonatology, Department of Paediatrics, Faculty of Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
  2. 2Department of Neonatal Medicine, Women's and Children's Hospital, Adelaide, South Australia, Australia
  3. 3Robinson Institute, University of Adelaide, Australia
  4. 4Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK
  1. Correspondence to Dr Amy K Keir, Division of Neonatology, Department of Paediatrics, Faculty of Medicine, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8; amy.keir{at}

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An otherwise well 4-week-old 28-week gestation male infant has a haemoglobin level of 69 g/l associated with a low reticulocyte count. He is currently on full enteral feeds. The medical plan is to give him a blood transfusion, but the nursing staff ask whether feeding should be stopped around the time of transfusion to reduce his chance of developing complications. What is the evidence that feeding practices during transfusion influence the risk of developing transfusion-associated necrotising enterocolitis (TANEC)?

Structured clinical question

In a preterm infant [patient] with anaemia of prematurity, do feeding practices [intervention] during blood transfusion reduce the risk of developing TANEC [outcome]?

Search strategy and outcome

MEDLINE (1966–2012), SUMsearch2, the Cochrane library and the Pediatric Academic Societies abstract archive (2000–2011) were searched using the terms: infant, newborn infant, preterm AND necrotising enterocolitis AND transfusion AND feeding, limited to human biology and paediatric population where possible.

A total of 342 articles were identified, of which …

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  • Contributors AKK had the idea for the article. AKK and DW performed the literature search and wrote the paper together. AKK is the guarantor for the paper.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.