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There are several ways in which antiretroviral treatment (ART) could protect against malaria. Proteases in HIV and in Plasmodium falciparum have biochemical similarities so antiretroviral protease inhibitors such as lopinavir may be active against P falciparum, and lopinavir has been shown to have antiplasmodial activity in vitro. Some antiretroviral drugs, including ritonavir, are potent enzyme inhibitors and may inhibit the metabolism of antimalarial …
Competing interests None.
Provenance and peer review Not commissioned; internally peer reviewed.