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Microarray versus karyotyping for antenatal diagnosis and after stillbirth

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Successive papers in a single issue of the New England Journal of Medicine have reported on the use of chromosomal microarray analysis in prenatal diagnosis and diagnosis after stillbirth (Ronal J Wapner and colleagues. N Engl J Med 2012;367:2175–84; Uma M Reddy and colleagues. Ibid: 2185–93; see also editorial, ibid: 2249–51).

The study on prenatal diagnosis included chorionic villus or amniotic fluid samples from 4406 women at 29 US centres. Samples for microarray analysis were available from 4391 women but 109 samples …

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  • Provenance and peer review Not commissioned; internally peer reviewed.