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The term histamine intolerance (HIT) describes a proposed disease in which patients develop a variety of symptoms following the ingestion of foods rich in histamine.1 ,2 Due to an assumed reduced activity of intestinal diamine oxidase (DAO), histamine-rich foods (eg, aged cheese, cured meat or sausages, fish) cause above-normal serum histamine levels.3 These elevated histamine levels cause various histamine receptor–mediated symptoms such as flush, headache or urticaria, and with respect to the gastrointestinal tract, diarrhoea and abdominal pain. In adults, measuring low DAO levels (<10 U/mL) in combination with improvement to a histamine-free diet has been suggested to be diagnostic for HIT.1 Chronic abdominal pain is a common problem in paediatric gastroenterology. In children, there is no study that addresses the question if HIT can be identified as the cause for chronic abdominal pain.
Within 26 months, 394 children presented with chronic abdominal …
Contributors KMH: designed the study, supervised the data collection, drafted the original manuscript and approved the final manuscript as submitted. EG: was responsible for the data collection, cowrote the manuscript and approved the final manuscript as submitted. AD: performed DBPC histamine challenge, cowrote the manuscript and approved the final manuscript as submitted. JJ: performed DBPC histamine challenge, cowrote the manuscript and approved the final manuscript as submitted. ACH: helped design the study, performed DBPC histamine challenge, reviewed and revised the manuscript and approved the final manuscript as submitted.
Competing interests None.
Ethics approval The local ethics committee of the Medical University Graz approved our study (24-392 ex 11/12).
Provenance and peer review Not commissioned; internally peer reviewed.