Article Text


329 Severe Retinopathy of Prematurity (ROP) Remains a Marker of Childhood Disabilities: Results from the Caffeine for Apnea of Prematurity Trial
  1. B Schmidt1,2,
  2. P Davis3,
  3. L Doyle3,
  4. P Anderson3,
  5. E Asztalos4,
  6. A Solimano5,
  7. R Grunau5,
  8. A Ohlsson4,
  9. D Dewey6,
  10. D Moddemann7,
  11. K Barrington8,
  12. W Tin9,
  13. R Roberts2 for the Caffeine for Apnea of Prematurity (CAP) Trial Investigators
  1. 1University of Pennsylvania, Philadelphia, PA, USA
  2. 2McMaster University, Hamilton, ON, Canada
  3. 3University of Melbourne, Melbourne, VIC, Australia
  4. 4University of Toronto, Toronto, ON
  5. 5University of British Columbia, Vancouver, BC
  6. 6University of Calgary, Calgary, AB
  7. 7University of Manitoba, Winnipeg, MB
  8. 8University of Montreal, Montréal, QC, Canada
  9. 9James Cook University, Middlesbrough, UK


Background The Cryotherapy for Retinopathy of Prematurity Cooperative Group showed that the severity of ROP was a marker for functional disability at 5.5 years in infants ≤1250 g BW who were born in the late 1980s.

Objective To determine whether severe ROP remains a strong predictor of visual and non-visual disabilities at age 5 years in infants ≤1250 g BW who were enrolled in the CAP trial between 1999 and 2004.

Methods 5-year follow up of 1580 surviving CAP children with known ROP status. Severe ROP was defined as stage 4 or 5 disease or receipt of retinal therapy in at least one eye. Outcomes were disabilities in 6 domains, and including cognitive impairment (Full Scale IQ< 70), motor impairment (GMFCS level 2–5), deafness and blindness. Odds ratios were adjusted for antenatal steroids, gestational age, sex, multiple birth, and mother’s education.

Results There were 94 survivors with and 1486 without severe ROP. Rates of visual and non-visual disabilitites were significantly higher in children with severe ROP (Table 1).

Abstract 329 Table 1

Conclusions Severe ROP remains a strong marker of childhood disabilities in a recent and large international cohort of infants ≤1250 g BW.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.