Background and Aim A common, early postpartum concern of the breastfeeding mother is nipple pain Because of lack of effective treatment and Opponent results about lanolin, we decided to compare effect of lanolin ointment and Aloevera gel on nipple sore treatment.

Methods This clinical blind trial was performed in Mashhad, Iran from Feb 2008 to May 2009. Sampling was nonrandom and purpositive and then samples divided randomly into two groups.

Mothers were instructed to rub the preparation on their arms and if there wasn’t cause allergy symptoms, rub it on the nipple after feeding the baby 3 times a day for 7 days and let to dry and don’t wash it before next feeding. Researcher pretreatment, at 3rd and 7^th day filled Storr scale with interview and examination There was no any complications in mothers and infants because of drug usage.

Then data was analyzed with Spss 11.5 and Mann-witney, t student and t-paired tests.

Results A total of 100 samples enrolled with 50 samples in lanolin group and 50 samples in aloevera group.

nipple sore scoring decreased significantly at 3^rd day versus pretreatment (p=0.00) also at 7^th day versus pretreatment and 3^rd day (p=0.000).

nipple sore scoring decreased significantly at 3^rd day versus pretreatment (p=0.00) also at 7^th day versus pretreatment and 3^rd day (p=0.000, p=0.001).

Two groups were homogenous concerning at pretreatment day (p=0.711), but there was a significant difference between 2 groups at 3^rd and 7^th day (p=0.048, p=0.003).

Conclusion Aloe Vera is more effective than lanolin on nipple sore healing.