Article Text

Download PDFPDF

1702 Increase Plasma Endothelin-1 Levels are Associated with Lung Hypertension in Low Birth Newborns with Omphalocele
  1. D Dmytriiev,
  2. O Katilov,
  3. O Mazulov,
  4. K Dmytriieva
  1. Anesthesiology and Intensive Care, Vinnitsa National Medical University, Vinnitsa, Ukraine


Objective Increased pulmonary vascular resistance in low birth newborn with omphalocele is suggested, and endothelin-1 plays an important role in pulmonary vascular reactivity in newborns.

Methods We determined plasma (second sample) levels of endothelin-1 in 12 low birth newborns with omphalocele and 14 without omphalocele (gestational ages: 26.2±1.4 and 25.4±1.6 weeks, respectively). Blood and a second blood sample taken 18 to 40 h after birth were used for endothelin-1 determination by enzyme immunoassay.

Result Plasma levers ET-1 concentrations were higher than second sample ET-1 levels in both groups (p<0.001). There was a significant positive correlation between second sample ET-1 and SNAPPE II (r = 0.32, p=0.01). There were no correlations between plasma ET-1 levels first sample and second sample ET-1 concentrations and 5-min Apgar score < 6. Duration of mechanical ventilation had a significant positive correlation with second sample ET-1 (r = 0.46, p=0.02). Plasma lever ET-1 levels did not differ between control and omphalocele (13.0 and 14.6 pg/mL, respectively, p=0.80). Second sample ET-1 levels had significantly higher ET-1 levels than controls (1.32 and 6.04 pg/mL, respectively, p=0.001).

Conclusion Our low birth newborn with and without omphalocele had similar plasma ET-1 levels, whereas ET-1 levels were higher in omphalocele than in control newborns 18 to 40 h after birth. The increased vascular resistance in omphalocele may be related to high ET-1 levels.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.