Article Text


164 Linear Growth after Pediatric Liver Transplantation
  1. W Saleem,
  2. H Abdelrahman,
  3. A Elawwa,
  4. A Soliman
  1. Pediatrics, Hamad Medical Center, Doha, Qatar


To determine growth patterns in a children undergoing liver transplantation, the outcomes of orthotopic liver transplantations performed in 10 children at Hamad General Hospital between October 2005 and October 2009 were reviewed. The mean age at transplantation was 27 +/– 30 months; 80% of the children were females. The transplants were from living-related donors. At the time of transplantation the mean height z score was - 1.15 +/– 1.7 and BMI z score was 0.44 +/– 1.8. Eighteen months after transplantation, catch-up growth was seen in 40% of children, 30% had normal linear growth without any catch-up and 30% had slow growth rate after transplantation. Children with evidence of catch-up growth (growth velocity z score >0) had more growth retardation at the time of transplantation, and were receiving lower doses of prednisone at 1.5 years after transplantation. Younger infants (below 6 months) were most likely to demonstrate catch-up growth after transplantation. In summary, a large proportion of children have growth retardation at the time of liver transplantation. Serum albumin increased significantly after (39.8+/–5.2 g/L) vs before (34 +/–11g/L)transplantation, and Alanine transferase (ALT) decreased significantly from (130+/–260U/L) to (30+/–15U/L). Poor growth after transplantation occurred more in those receiving higher doses of corticosteroid. This growth retardation is inversely correlated with age. Growth after transplantation is proportional to the degree of growth retardation at transplantation and inversely correlated to age at transplantation.

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