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1152 Prostaglandin E 1 Use In The Transfer Of Infants With Suspected Duct Dependent Congenital Heart Disease
  1. N Gupta1,2,
  2. COF Kamlin2,3,
  3. M Stewart2,4,
  4. M Cheung5,
  5. N Patel4
  1. 1Neonatal Unit, John Radcliffe Hospital, Oxford, UK
  2. 2Newborn Emergency Transport Services (NETS), Royal Children Hospital
  3. 3Department of Newborn Research, Royal Womens Hospital
  4. 4Neonatal Unit, Royal Childrens Hospital
  5. 5Department of Cardiology, Royal Children Hospital, Melbourne, VIC, Australia


Background Transport of infants with suspected duct dependent congenital heart disease (DDCHD) represents a diagnostic and therapeutic dilemma, specifically in relation to use of prostaglandin E1 (PGE1) to maintain ductal patency.

Aims To evaluate factors influencing, and consequences of, PGE1 use in transport of infants with suspected DDCHD or persistent pulmonary hypertension (PPHN).

Methods Retrospective study of infants’ ≤10 days old with suspected DDCHD/PPHN transferred to the Royal Children’s Hospital, Melbourne, by NETS (Victoria) identified from transport and hospital databases.

Results Of 142 eligible infants, 81 had DDCHD, 51 had PPHN and 10 had neither. Diagnostic accuracy of DDCHD by transport team was 77%. PGE1 was commenced in 50% of infants, 63% of DDCHD group, and 19% of non-DDCHD group.

“Time critical” transfers were significantly associated with PGE1 use; transfer distance and air/land were not. PGE1 use was significantly associated with the presence of cyanosis, abnormal pulses and lower initial SpO2 and PaO2.

Ventilation and inotrope use during transfer were significantly higher in infants with DDCHD who received PGE1, than those who did not (both P 0.007). Use of PGE1 significantly shortened length of stay in PPHN but not DDCHD patients. There was no significant difference in death rates between PGE1 and no-PGE1 group.

Conclusions Although the ability of transport personnel to differentiate DDCHD from PPHN and correctly administer PGE1 was high, 35% of infants with DDCHD were transferred without PGE1. Cyanosis, abnormal pulses and initial hypoxemia influenced the decision to start PGE1. PGE1 may improve outcome in PPHN.

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