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1098 Cardiac Output Measurements in Preterm Neonates Requiring Resuscitation at Birth
  1. N Ahmed,
  2. V Sundaram,
  3. P Kumar
  1. PGIMER, Chandigarh, India


Background The effect of perinatal asphyxia on cardiac output and flow patterns in asphyxiated preterm neonates is less well understood.

Objectives To study the cardiac outputs (left and right ventricle – LVO and RVO) and superior vena cava (SVC) blood flow patterns in asphyxiated preterm neonates in first 24 hours of age.

Subject and interventions Serial echocardiography was done in preterm neonates < 34 weeks who required resuscitation, at 6±2, 12±2 and 24±4 hours using color Doppler (Sonosite). LVO, RVO and SVC flow velocity were calculated .

Results Functional Echo was done in 68 neonates with mean gestation and weight of 31±1.6 weeks and 1343± 361g. Median SVC flow, LVO and RVO at 6, 12 and 24 hrs of age were 109 (70–137), 103 (85–150) and 132 (92–181); 381 (287–493), 421 (337–510) and 408 (324–557); 327 (214–435), 328 (259–467) and 381 (280–501) ml/kg/min respectively. The differences in these three measures between three time points were not statistically significant. A statistically significant increase was seen between SVC flows at 6 versus 24 hours. No difference was observed in these measurements in 21% vs 100% oxygen groups.

Conclusions LVO, RVO and SVC flow showed an increasing trend from 6 hrs of age to 24 hrs of age. A significant increase was observed in the SVC flow between 6 and 24 hours of age suggestive of hypoperfusion-reperfusion phenomena. Resuscitating with 21% or 100 % oxygen did not show any difference in these measurements.

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