Backround: Iron deficiency anemia (IDA) and thalassemia are the most common microcytic anemia in children. Sometimes, expensive or invasive investigations are necessary for their distinction. Red cell distribution - coefficient variation (RDW-CV) is a new generation marker more often used in differentiating IDA from thalassemia. A number of hematological indices are also useful (Mentzer, Shine&Lal, Green&King, Ricerca).
Aim To demonstrate the effectiveness RDW - CV in differentiating microcytic anemia.
Method Retrospective study conducted on a total of 215 patients with microcytic anemia. Criteria for study group selection: MCV and Hb below the minimum age reference (mild anemia, Hb between 9–11 g/dl and moderate anemia from 8.5–9 g/dl), without a history of other hematologic disorders or chronic diseases.
Sideremia was determined to all patients to confirm the diagnosis of IDA (the least expensive investigation for distinction). The RDW - CV > 16% was considered pathological.
Results 98 patients had low levels of sideremia, 134 patients had mild anemia and 81 - moderate anemia. RDW-CV was significantly correlated with sideremia, strongly for the group with mild anemia (p<0.05). Statistical significance was observed for Shine&Lal (p<0.006), Green & King (p<0.005), Ricerca (p<0.05). The greatest sensitivity presented Green&King (72%), followed by Shine&Lal and Ricerca, and the highest specificity Shine&Lal and Ricerca (92%).
Conclusions RDW-CV is useful in differentiating IDA, especially in mild forms. Although Green&King index is the most sensitive, we support Ricerca index for simple calculation formula.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.