Background Spirometry and biomarkers such as immunoglobulin E (IgE) levels, fractional exhaled nitric oxide concentration (FeNO) have been proposed for assessing the risk of future adverse events in Expert Panel Report 3 (US National Asthma Education and Prevention Program).
Objectives Evaluating the interrelationship between spirometry parameters and/or biomarkers levels (IgE, FeNO, blood eosinophils percentage) and specific symptoms in asthmatic children between hospitalization episodes.
Material and Methods 40 asthmatic pacients were evaluated performing spirometry and measuring biological parameters (Ig E levels, blood eosinophils, Fe NO). Symptoms like cough, dispnoea, wheezing described in patients diaries were analysed in correlation with the spirometric and biological parameters using t-Test, Mann-Whitney test, Pearson correlations. For each symptom analysed, every time two groups have emerged (with symptoms or without symptoms).
Results Blood eosinophils were different for each symptom, p<0.05 comparing each time the groups. The tendency for positive corelations p=0.08 was noticed between FeNO and FEV1 (forced expiratory vital capacity). Positive corelations, p<0.05 were found between studied parameters, most of the time in the same group (either the group with symptoms or the group without symptoms).
Conclusions Blood eosinophils and IgE levels may be regarded more as global predictors but FEV1 and FeNO may be considered more accurate predictors in risk assessment of future adverse events.
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