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616 Morbidity Due to Acute Lower Respiratory Infections (ALRI) in Children with Birth Defects: a Total Population Linked Data Study
  1. K Jama-Alol
  1. Centre for Health Services Research, School of Population Health, The University of Western Australia, Perth, WA, Australia


Background Acute lower respiratory infections (ALRIs) remain the leading cause of hospitalisation among children < 2 years old. Birth defects occur in 5% of live births in Western Australia (WA), and are a major cause of childhood morbidity and mortality. However ALRI hospitalisation rates among children with various birth defects are unknown.

Methods We conducted a retrospective cohort study of 245,249 singleton births in WA (1996–2005). Population-based hospital morbidity data and the WA Register of Development Anomalies were linked through the Western Australian Data Linkage System to investigate ALRI hospitalisations in children with and without birth defects. We used negative binomial regression to estimate incidence rate ratios (IRR) for the association between birth defects and number of ALRI hospitalisations over the first 2 years of life, adjusting for known risk factors.

Results Overall 11% of non-Aboriginal children and 40% of Aboriginal children with birth defects had a least one ALRI admission before age 2 years. In adjusted analyses, Aboriginal and non-Aboriginal children were more likely to be hospitalised for ALRI if they had a birth defect than children with no birth defects (IRR 2.29, 95% CI: 1.89, 2.78; IRR 2.00, 95% CI: 1.84, 2.17 respectively).

Conclusions WA children < 2 years with birth defects are at greater risk of morbidity due to ALRIs, when compared to children with no birth defects. Risk of ALRI hospital admission varies between different birth defect categories.

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