Background and aim Perfluorocarbon (PFC) aerosolization is feasible; however, it is unknown whether aerosolization is better than Partial Liquid Ventilation (PLV).
Methods 18 preterm lambs were randomly assigned to receive aerosolized PFC (10 ml/kg/h for 2h) delivered via an inhalation catheter, (PFC-aero group), instilled intratracheal PFC (20 ml/kg; PLV group), or just mechanical ventilation (CONTROL group). Gas exchange, pulmonary mechanics, and histological scores were assessed. Mean ± SD, ANOVA, p<0.05.
Results Both PFC administration techniques significantly improved gas exchange and pulmonary mechanics compared to CONTROL group (two-way ANOVA). 15 minutes after PLV, OI and VEI were significantly better in the PLV group compared to other groups. However, in terms of OI, aerosolized PFC remained significantly better than CONTROL group for the entire observational period (360 min), whereas at 240 min and on, the differences between PLV and CONTROL groups were not significant. PLV and aerosolized PFC significantly decreased the degree of atelectasis but did not significantly improve the general histological score.
Conclusion Both PFC administration techniques show pulmonary efficacy in RDS. Future research should focus on the PFC aerosol delivery efficiency.
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