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434 Relationship between Obesity and 8-Hydroxy 2- Deoxy Guanosine as an Oxidative Marker in Obese Adolescents of Giza
  1. E Abdel Hameed1,
  2. A El Wakkad2,
  3. NEM Hassan3,
  4. L Sherif1,
  5. A Abd El-Shaheed1,
  6. H Sebii2,
  7. S El Zayat2
  1. 1Child Health
  2. 2Physiology
  3. 3Anthropology, National Research Centre, Cairo, Egypt


Background and Aim This study was conducted to assess the relationship between obesity markers (Body mass index “BMI”, fat percentage) and DNA oxidative marker 8-hydroxyl guanosine (OHG), as a predictor for future clinical problems in obese adolescents of Giza.

Methods The study was conducted on 103 adolescents aged 13–18 years (22 boys, 81 girls). BMI was calculated as body weight (kg) divided by height (m2) squared and obesity was defined as BMI of 95 percentile. Fat percentage was determined by using Biological impedance technique. Oxidative stress markers as 8-hydroxyl guanosine, superoxide and gluthione were measured. The adolescents were divided according to BMI into two groups. Group I with BMI > 95 percentile and less than 97 percentile (obese) and Group ∩ with BMI > 97 percentile (severely obese).

Results Significant differences were detected between the two groups of the study as regard obesity markers (BMI, fat %) and oxidative stress markers (lipid oxidation, superoxide dismutase enzyme activity, glutathione peroxidase enzyme activity, 8-hydroxyl guanosine) (p<0.0005). Significant positive correlations were detected between obesity markers and oxidative stress markers among severely obese adolescent (group II). Obesity is highly associated with states of oxidative stress in adolescents, with a positive relation with 8-hydroxy-guanosine and obesity markers and other oxidative markers.

Conclusion This marker might play an important role in the prediction of future development of some clinical diseases.

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