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386 A Count of three Neonatal Morbidities may Substitute for Long-Term Neurodevelopmental follow-up in very Low Birth Weight (VLBW) Infants
  1. B Schmidt1,2,
  2. R Roberts2,
  3. P Davis3,
  4. L Doyle3,
  5. E Asztalos4,
  6. G Opie5,
  7. A Bairam6,
  8. A Solimano7,
  9. S Arnon8,
  10. R Sauve9 for the Caffeine for Apnea of Prematurity (CAP) Trial Investigators
  1. 1University of Pennsylvania, Philadelphia, PA, USA
  2. 2McMaster University, Hamilton, ON, Canada
  3. 3University of Melbourne, Melbourne, VIC, Australia
  4. 4University of Toronto, Toronto, ON, Canada
  5. 5Mercy Hospital, Melbourne, VIC, Australia
  6. 6Laval University, Quebec, QC
  7. 7University of British Columbia, Vancouver, BC, Canada
  8. 8Meir Medical Centre, Kfar Saba, Israel
  9. 9University of Calgary, Calgary, AB, Canada


Background In very preterm infants who survive to a postmenstrual age (PMA) of 36 weeks, a count of BPD, brain injury and severe ROP predicts the risk of a later death or neurosensory impairment at 18 months (JAMA 2003; 289:1124).

Objective To validate this count of 3 neonatal morbidities as a predictor of poor long-term outcome in VLBW infants who participated in the CAP Trial.

Methods Five-year follow-up of 1514 CAP trial participants who survived to a PMA of 36 weeks. Poor outcome was a late death or survival with one or more disabilities.

Results The incidences of BPD, brain injury and severe ROP were 40%, 13%, and 6.0%, respectively. Each morbidity was similarly and independently correlated with a poor 5-year outcome. Table 1 shows the risks of a poor long-term outcome with none, any 1, any 2, and all 3 neonatal morbidities.

Abstract 386 Table 1

Conclusions In VLBW infants who survive to a PMA of 36 weeks, a count of BPD, brain injury and severe ROP predicts the risk of a later death or survival with disability at age 5 years. This morbidity count may substitute for long-term outcome assessments in very preterm infants whose families do not comply with neurodevelopmental follow up.

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