Article Text

Download PDFPDF
Practical issues in relation to clinical trials in children in low-income countries: experience from the front line
  1. Elizabeth Molyneux1,
  2. Don Mathanga2,
  3. Desiree Witte3,
  4. Malcolm Molyneux4
  1. 1Paediatric Department, College of Medicine, Blantyre, Malawi
  2. 2Malaria Alert Centre, College of Medicine, Blantyre, Malawi
  3. 3Faculty of Life and Health Sciences, University of Liverpool, Liverpool, UK
  4. 4Medicine Department, College of Medicine, Blantyre, Malawi
  1. Correspondence to Professor Eizabeth Molyneux, College of Medicine, Paediatric Department, Blantyre Box 360 Malawi; emmolyneux{at}


Clinical trials in children in resource-poor environments are essential for local health policy and practice to be relevant and evidence based. Research must be ethical, appropriate, relevant and of good quality. It should, where possible, benefit the subjects studied,the clinical, scientific and support staff involved, and the service and academic institutions of the host country. The challenge for researchers and their sponsors is to maximise such benefits while avoiding the many possible pitfalls.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.

Linked Articles

  • Atoms
    Imti Choonara