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Investigation and management of hypercalcaemia in children
  1. Justin H Davies1,
  2. Nicholas J Shaw2
  1. 1Department of Paediatric Endocrinology, University Hospital Southampton, Southampton, UK
  2. 2Department of Endocrinology and Diabetes, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK
  1. Correspondence to Dr Justin Huw Davies, Department of Paediatric Endocrinology, University Hospital Southampton, Tremona Road, Southampton SO16 6YD, UK; justin.davies{at}


Hypercalcaemia is a far less common finding in children than in adults. It may present with characteristic symptoms or may be identified as a coincidental finding in children investigated for a variety of complaints. Assessment of hypercalcaemia requires an understanding of the normal physiological regulation of plasma calcium by the combined actions of parathyroid hormone, 1,25-dihydroxyvitamin D3 and the calcium sensing receptor. Hypercalcaemia will usually require treatment using a number of different modalities but occasionally it can be due to a benign asymptomatic condition that requires no intervention. This article presents a logical approach to the investigation and subsequent management of this condition.

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  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.