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In children with clinical signs of sepsis, inflammatory parameters in blood, bacterial cultures of blood, urine and cerebrospinal fluid (CSF), and viral diagnostics (herpes simplex virus) and enteroviruses (EV) in CSF and EV in faeces) are often examined, mostly followed by hospital admission and empiric antibiotic treatment.
Human parechovirus (HPeV) has been identified and described as cause of sepsis-like illness, meningitis and occasionally encephalitis in children.1 Timely diagnosis of HPeV infection can influence the decision to discontinue antibiotic treatment.
To establish the incidence of HPeV and EV infection, we retrospectively performed PCR analysis on CSF and faecal samples from children (birth to 18 years) with …
Provenance and peer review Not commissioned; externally peer reviewed.
Competing interests None.