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Cow's milk allergy and rolandic epilepsy: a close relationship?
  1. Sandra Lucarelli,
  2. Alberto Spalice,
  3. Ylenia D'Alfonso,
  4. Ginevra Lastrucci,
  5. Simona Sodano,
  6. Lucia Topazio,
  7. Tullio Frediani
  1. Department of Pediatrics, Sapienza University of Rome, Rome, Italy
  1. Correspondence to Sandra Lucarelli, Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324 –00161, Rome, Italy; sandra.lucarelli{at}

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Over many years in paediatric allergology we (SL and TF) have observed a higher incidence of allergy in the children with epilepsy and their immediate families than in the controls and their families.1 It has nevertheless proved impossible to demonstrate a strict correlation between allergy and epilepsy, and most of the reports are anecdotal and open to any and every aetiological hypothesis.2 Interest in food allergy as a cause or aggravating factor of epilepsy was reawakened by Egger, whose studies on children suffering from migraine and/or hyperactive syndrome reported an improvement in the convulsive symptomatology subsequent to an oligoantigenic diet.3 Rolandic epilepsy is the best known and described form of idiopathic epilepsy and unquestionably the …

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  • Competing interests None.

  • Patient consent Obtained from the parents/guardians.

  • Ethics approval Approval for the study was obtained from the Ethics Committee, Policlinico Umberto I Hospital, Rome, Italy.

  • Provenance and peer review Not commissioned; externally peer reviewed.