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Question 3 Does the administration of glucagon improve the rate of radiological reduction in children with acute intestinal intussusception?
  1. Francois Cachat1,
  2. Pascal Ramseyer2
  1. 1Department of Paediatrics, University Hospital, Lausanne, Switzerland
  2. 2Department of Paediatric Surgery, University Hospital, Lausanne, Switzerland
  1. Correspondence to Francois Cachat, Department of Paediatrics, University Hospital, Lausanne 1011, Switzerland; fcachat{at}

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A 6-month-old boy presents to the paediatric emergency department with acute paroxysmal abdominal pain, vomiting and bloody stools. Your suspicion of intestinal intussusception is soon confirmed by an abdominal ultrasound. You are planning radiological reduction of the intussusception. You have heard that glucagon could be given to increase the chance of reduction, and you are wondering if you should administer it.

Structured clinical question

In an infant [patient] with acute intestinal intussusception [condition], does the administration of glucagon [intervention] increase the rate of radiological reduction [outcome]?

Search strategy

Primary sources

A systematic review of the literature from 1966 to September 2011 was carried out. The Medline, Embase and Web of Science databases were searched. The Medline search strategy used both medical subject headings (MeSH) and free-text protocols. Specifically, the MeSH search was conducted by combining the following retrieved from the MeSH browser provided by Medline: intussusception AND glucagon AND randomized controlled trial. No limits were set. The searches on Embase and …

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  • Competing interests None.

  • Provenance and peer review Not commissioned, externally peer reviewed.