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Necrotising enterocolitis (NEC) is a leading cause of mortality in preterm neonates.1 ,2 Despite the central role of innate immune inflammatory components in the pathogenesis of NEC,2 the potential diagnostic utility of these mediators remain largely uninvestigated. Measurement of serum levels of S100 myeloid-related proteins A8/A9 (S100 A8/A9), one of the principal mediators of innate immune response, has been proposed as diagnostic marker for several inflammatory conditions including neonatal sepsis.3 In the present study we aimed to evaluate the diagnostic accuracy of S100 A8/A9 in neonates with NEC.
In a prospective multicentre study we enrolled neonates with gestational age (GA) <32 weeks with suspected NEC, according to standardised Bell criteria.2 Exclusion criteria were genetic syndromes, …
Contributors GT and RBC designed the study and coordinated the research team, RP and AP enrolled the patients and wrote the first draft of the study, AP also performed monitoring of the data, MDC contributed to the design of the study and to the final version of the manuscript.
Competing interests None.
Patient consent Obtained.
Ethics approval University of Naples Federico II.
Provenance and peer review Not commissioned; externally peer reviewed.
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