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S100 A8/A9 protein as a marker for early diagnosis of necrotising enterocolitis in neonates
  1. Gianluca Terrin1,
  2. Annalisa Passariello2,
  3. Mario De Curtis3,
  4. Roberto Paludetto4,
  5. Roberto Berni Canani5
  1. 1Department of Gynecology-Obstetrics and Perinatal Medicine, University “La Sapienza”, Rome, Italy
  2. 2Department of Intensive Care, Hospital “Dei Colli”, Naples, Italy
  3. 3Department of Pediatrics, University “La Sapienza”, Rome, Italy
  4. 4Department of Pediatrics, University of Naples “Federico II”, Naples, Italy
  5. 5Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University of Naples “Federico II”, Naples, Italy
  1. Correspondence to Dr Gianluca Terrin, Department of Gynecology-Obstetrics and Perinatal Medicine, University “La Sapienza”, Rome, Italy, Viale del Policlinico 155, Rome 00161, Italy; gianluca.terrin{at}

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Necrotising enterocolitis (NEC) is a leading cause of mortality in preterm neonates.1 ,2 Despite the central role of innate immune inflammatory components in the pathogenesis of NEC,2 the potential diagnostic utility of these mediators remain largely uninvestigated. Measurement of serum levels of S100 myeloid-related proteins A8/A9 (S100 A8/A9), one of the principal mediators of innate immune response, has been proposed as diagnostic marker for several inflammatory conditions including neonatal sepsis.3 In the present study we aimed to evaluate the diagnostic accuracy of S100 A8/A9 in neonates with NEC.

In a prospective multicentre study we enrolled neonates with gestational age (GA) <32 weeks with suspected NEC, according to standardised Bell criteria.2 Exclusion criteria were genetic syndromes, …

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  • Contributors GT and RBC designed the study and coordinated the research team, RP and AP enrolled the patients and wrote the first draft of the study, AP also performed monitoring of the data, MDC contributed to the design of the study and to the final version of the manuscript.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval University of Naples Federico II.

  • Provenance and peer review Not commissioned; externally peer reviewed.