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Vitamin D in children with cystic fibrosis
  1. Malcolm Brodlie1,2,
  2. William A Orchard2,
  3. Gordon A Reeks2,
  4. Stewart Pattman3,
  5. Helen McCabe2,
  6. Christopher J O'Brien2,
  7. Matthew F Thomas2,
  8. David Anthony Spencer2
  1. 1Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
  2. 2Regional Paediatric Cystic Fibrosis Service, Department of Paediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
  3. 3Chemical Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
  1. Correspondence to Dr Malcolm Brodlie, c/o Paediatric Respiratory Secretaries, Old Children's Outpatients Department, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK; m.j.brodlie{at}


Purpose The Cystic Fibrosis Trust in 2007 published a recommended target of 75-150 nmol/L for 25-hydroxyvitamin D (25-OHD). In 2008 we found that only 10% of pancreatic insufficient (PI) children met this target. An increase in supplementation was implemented and a repeat audit performed in 2010.

Methods PI children ≥1 year under sole-care in our regional centre were included. Vitamin D3 supplementation increased by >450% to either 3800 IU/day liquid or 800 IU daily plus 20,000 IU weekly tablets. In 2010 pancreatic sufficient (PS) children were also audited separately.

Results The median 25-OHD level increased from 51.5 nmol/L in 2008 (n=78, 10% >75 nmol/L) to 72 nmol/L in 2010 (n=72, 51% >75 nmol/L), p<0.0001. In PS children (n=15 in 2010) 87% had 25-OHD levels <75 nmol/L.

Conclusions A substantial increase in supplementation led to a significant increase in 25-OHD levels but around half still failed to reach the recommended target.

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