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Hypothyroidism is a frequently encountered endocrine disorder, and severe untreated juvenile hypothyroidism may manifest as precocious puberty with ovarian enlargement, a clinical triad first described by Van Wyk and Grumbach in 1960.1
It is important to recognise this syndrome because unnecessary ovarian surgery can be avoided as the clinical features, in particular ovarian enlargement, can be reversed with thyroxine replacement alone.2 ,3 However, ovarian torsion as …
Contributors Dr Rashida F Vasanwala and Dr Jeremy MJ Ho, prepared the concept, design, intellectual content, and did the literature search for the manuscript. Dr Ong Lin Yin and Dr Fabian Yap, helped in reviewing and editing the manuscript.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
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