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A 3-year-old boy was seen in the community paediatric clinic for follow up of his Duchenne muscular dystrophy (DMD). There have been recent discussions about starting him on steroids. His parents would like to know if treatment with glucocorticoid corticosteroids (GCs) has been shown to prolong ambulation and the best age to start steroids. They also want to know if steroids reduce the complications of DMD and if the side effects of long-term steroids are acceptable.
Structured clinical question
In children with Duchenne muscular dystrophy [patients], do glucocorticoid corticosteroids [intervention] prolong ambulation, improve muscle function and reduce complications [outcomes]?
Search strategy and outcome
A search of The Cochrane Library yielded one relevant review.
Advanced searches of MEDLINE and EMBASE were carried out.
Search terms were Duchenne muscular dystrophy, muscular dystrophy, Duchenne, steroids, corticosteroids, glucocorticoids.
A total of 249 studies were …
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