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Enteroviral meningitis without pleocytosis in children
  1. Ki Wook Yun1,2,
  2. Eun Hwa Choi1,3,
  3. Doo Sung Cheon4,
  4. Jina Lee5,
  5. Chang Won Choi1,5,
  6. Hee Hwang5,
  7. Beyong Il Kim1,5,
  8. Kyoung Un Park6,
  9. Sung Sup Park6,
  10. Hoan Jong Lee1,3
  1. 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
  2. 2Department of Pediatrics, Chung-Ang University College of Medicine, Seoul, Korea
  3. 3Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea
  4. 4Division of Enteric and Hepatitis Viruses, Center for Infectious Diseases, National Institutes of Health, Korea Center for Disease Control and Prevention, Osong, Korea
  5. 5Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea
  6. 6Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
  1. Correspondence to Professor Eun Hwa Choi, Department of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-769, Korea; eunchoi{at}


Objectives This study aims to describe the clinical characteristics of enteroviral meningitis in association with the absence of cerebrospinal fluid (CSF) pleocytosis.

Design This was a retrospective analysis of databases of patients diagnosed with enteroviral meningitis by CSF reverse transcription-PCR testing. Presence of CSF non-pleocytosis at each age group was analysed by use of the two criteria. Clinical variables were compared with regard to the presence of CSF pleocytosis. Multiple logistic regression analysis was used to identify factors that were associated with CSF pleocytosis.

Setting Two hospitals in South Korea, between January 2008 and August 2011.

Patients 390 infants and children with enteroviral meningitis.

Interventions None.

Main outcome measures Proportion of enteroviral meningitis without CSF pleocytosis.

Results Among the 390 patients with enteroviral meningitis, 16–18% did not have CSF pleocytosis. In particular, CSF pleocytosis was not present in 68–77% of the neonates with enteroviral meningitis, demonstrating that the proportion of CSF pleocytosis decreased significantly with age (p<0.001). In multivariate models, younger age (adjusted OR 0.981; 95% CI 0.973 to 0.989), lower peripheral white blood cell count (adjusted OR 0.843; 95% CI 0.791 to 0.899), and shorter interval between onset and lumbar puncture (adjusted OR 0.527; 95% CI 0.315 to 0.882) were associated with the absence of CSF pleocytosis in enteroviral meningitis.

Conclusions This study demonstrated high proportion of non-pleocytic enteroviral meningitis in young infants and identified several clinical factors that contributed to the absence of CSF pleocytosis. We suggest that CSF enterovirus PCR testing is likely to detect more cases of enteroviral meningitis, especially in young infants.

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