Neonatal infection with herpes simplex virus (HSV) presents in various ways with varying outcomes. It may be fairly benign with skin, eye and mouth involvement only, no risk of death, and a very low risk of neurological impairment although there may be skin recurrences. Disseminated disease, however, is associated with a 30% mortality and a 20% risk of neurological sequelae among survivors. Central nervous system (CNS) infection is associated with a 6% mortality but a 70% risk of permanent neurological sequelae. The …