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Does a single measurement of exhaled nitric oxide predict asthma exacerbations?
  1. Chantal A N Visser1,
  2. Paul L P Brand1,2
  1. 1Princess Amalia Children's Clinic, Isala Klinieken, Zwolle, The Netherlands
  2. 2UMCG Postgraduate School of Medicine, University Medical Centre Groningen, Groningen, The Netherlands
  1. Correspondence to Paul L P Brand, Princess Amalia Children's Clinic, Isala Klinieken, Zwolle, The Netherlands; p.l.p.brand{at}

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The fraction of exhaled nitric oxide in exhaled air (FeNO) is considered to be a reliable marker of airway inflammation in asthma.1 High FeNO levels after withdrawal of inhaled corticosteroids (ICS) are associated with increased risk of impending asthma exacerbation.2 We conducted a prospective study in 103 6–16-year-old children with asthma (62% male, mean (SD) forced expiratory volume in 1 s (FEV1) 101.0 (12.1) % predicted), who had …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.