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Recurrent laryngeal papillomatosis: successful treatment with human papillomavirus vaccination
  1. Peter Mudry1,
  2. Martin Vavrina1,
  3. Pavel Mazanek1,
  4. Michaela Machalova2,
  5. Jiri Litzman3,
  6. Jaroslav Sterba1,4
  1. 1Department of Paediatric Oncology, University Children's Hospital Brno, Brno, Czech Republic
  2. 2ENT Department, University Children's Hospital Brno, Brno, Czech Republic
  3. 3Department of Clinical Immunology and Allergology, St. Anne's University Hospital, Brno, Czech Republic
  4. 4Masaryk University School of Medicine, Brno, Czech Republic
  1. Correspondence to Peter Mudry, Department of Paediatric Oncology, University Children's Hospital Brno, Cernopolni 9, 662 63 Brno, Czech Republic; pmudry{at}


The authors describe the case of a 5-year-old girl with recurrent laryngeal papillomatosis (RLP) due to human papillomavirus (HPV) type 11, who required frequent surgical treatment. Complete recovery occurred after HPV vaccination (Gardasil). Confirmed remission of RLP has continued during the 17 months of follow-up since vaccination. The authors conclude that HPV vaccination may represent a new therapeutic option in this situation.

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  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.