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Specific oral tolerance induction in food allergic children: is oral desensitisation more effective than allergen avoidance?
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  • Published on:
    To the Editor,
    • Elena Neri
    • Other Contributors:
      • Lorenza Matarazzo, Luca Ronfani

    We appreciated the meta-analysis of Fisher, du Toit and Lack about specific oral tolerance induction (SOTI) but we believe that some issues deserve to be highlighted. Three randomized controlled trials met the inclusion criteria. Of these, only one (Staden at al.) shows no differences between SOTI and control patients (Figure 2). This study includes a very young population (average 2.5 years with a six month old patient...

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    Conflict of Interest:
    None declared.
  • Published on:
    Which are specific oral tolerance induction goals ?
    • Egidio Barbi, MD
    • Other Contributors:
      • Giorgio Longo, Irene Berti

    To the Editor,

    we appreciated the meta-analysis by Fisher et al about specific oral tolerance induction (SOTI) in food allergic children (1), but we take exception to their statement about SOTI goal. The authors highlight as a substantial limit the fact that although SOTI increased the threshold of reactivity only few children were able to consume an age appropriate portion of the relevant food and fewer a...

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    Conflict of Interest:
    None declared.