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Tuberous sclerosis (or the tuberous sclerosis complex) is an autosomal dominant disorder with a birth prevalence of around 1 in 6000 live births. Subependymal giant-cell astrocytomas occur in 5–20% of patients, typically as slow-growing tumours in the region of the foramen of Monro. Surgery to remove these tumours may be difficult and incomplete. Activation of the mammalian target of rapamycin (mTOR) complex is the basis of tumour growth …
Provenance and peer review Not commissioned; internally peer reviewed.