Article Text

Download PDFPDF
Tuberous sclerosis: everolimus for subependymal giant-cell astrocytomas

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Tuberous sclerosis (or the tuberous sclerosis complex) is an autosomal dominant disorder with a birth prevalence of around 1 in 6000 live births. Subependymal giant-cell astrocytomas occur in 5–20% of patients, typically as slow-growing tumours in the region of the foramen of Monro. Surgery to remove these tumours may be difficult and incomplete. Activation of the mammalian target of rapamycin (mTOR) complex is the basis of tumour growth …

View Full Text


  • Provenance and peer review Not commissioned; internally peer reviewed.