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Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone
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  • Published on:
    Re:Please correct me if I am wrong ...

    Thank you for taking the time to respond to the paper. What we need to be quite clear about is the purpose and safety of this therapy. Antipyresis is not a necessary outcome, we know that many parents worry a lot about fever and this is a fear that is shared by quite a lot of parents. We also know that we have two very good drugs, which are generally very safe.

    By combining drugs we are saying to parents f...

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    Conflict of Interest:
    None declared.
  • Published on:
    anecdotal evidence should provisionally inform clinical practice

    Notwithstanding the statement made in the recommendation made by the Italian Pediatric Society Guidelines that "paracetamol and ibuprofen are generally well tolerated[as antipyretics]...when used at the recommended dosage"(1), and also notwithstanding the fact that "there are few data regarding toxicity[of either ibuprofen or paracetamol]..." and that "no conclusions can be reached regarding safety of any treatments"(2),...

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    Conflict of Interest:
    None declared.
  • Published on:
    Please correct me if I am wrong ...

    I'm a busy paediatrician and commonly commit the sin of reading an article's conclusions and ignoring the data presented. In that context I was amazed to see the dissonance between the conclusions of both the editorial and the paper "Systemic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone" with the actual data presented. The conclusions of both seem to have been clear...

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    Conflict of Interest:
    None declared.