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Melatonin in autistic spectrum disorders: meta-analysis

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The reported prevalence of sleep disorders among children with autistic spectrum disorders (ASD) is between 40% and 86%. The sleep disorders include taking longer to fall asleep (longer sleep onset latency), frequent waking during the night and shorter sleep. There may be associated mood disorders and other problems such as gastrointestinal disorders. It has been suggested that abnormal melatonin secretion might be involved in the development …

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  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.