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Although commonly found in adults with the nephrotic syndrome, membranous nephropathy is a rare cause of childhood nephrotic syndrome. The underlying pathogenesis involves the formation of subepithelial deposits of immune complexes in the glomeruli. Exogenous antigens may be involved in cases secondary to hepatitis B or C, congenital syphilis, systemic lupus erythematosus and some cancers. Two endogenous antigens have been described: neutral endopeptidase (in neonatal …
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