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Bronchospasm and airway remodelling in asthma

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In the treatment of asthma, the control of airway eosinophilic inflammation has been considered to be of prime importance in recent decades. Airway remodelling (goblet cell hyperplasia, subepithelial collagen deposition and smooth muscle hypertrophy on bronchial biopsy) is considered to be the basis of long-term deterioration of lung function in patients with asthma and has been attributed mainly to eosinophilic airway inflammation. Recently, however, …

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