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Treating the wrong children with fluids will cause harm: response to ‘mortality after fluid bolus in African children with severe infection’
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  • Published on:
    Caution in extrapolating the FEAST Trial findings to surgical hypovolaemic shock.
    • Kokila Lakhoo, Paediatric Surgeon
    • Other Contributors:
      • Stewart Cleeve (Paediatric Surgery Registrar)

    Dear Editor,

    We read the findings of the Feast Trial Group with interest and agree with many comments that the results appear counter-intuitive. Given our experience of managing children with hypovolaemic shock secondary to a surgical cause, in Africa and beyond, we feel that it is necessary to state that the findings of The FEAST trial should not be extrapolated to hypovolaemic shock secondary to a surgical cau...

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    Conflict of Interest:
    None declared.
  • Published on:
    Mortality of severe anemia increased by fluid resuscitation

    The Editorial by Drs.Southall and Samuels pointed out that fluid challenges given in a recent study by Maitland et al. (1) to children in the absence of hypovolemic shock may worsen severe anaemia. It is important to note that 32% of all children enrolled had severe anemia (Hb<5 g/dl) with no significant difference of this proportion between groups. Maitland et al. stated that their data showed that excess mortality w...

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    Conflict of Interest:
    None declared.