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Routine educational outcome measures in health studies: Key Stage 1 in the ORACLE Children Study follow-up of randomised trial cohorts
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  1. David R Jones1,
  2. Katie Pike2,
  3. Sara Kenyon2,
  4. Laura Pike1,
  5. Brian Henderson3,
  6. Peter Brocklehurst4,
  7. Neil Marlow5,
  8. Alison Salt6,
  9. David J Taylor2
  1. 1Health Sciences Department, University of Leicester, Leicester, UK
  2. 2Cancer and Molecular Medicine Department, University of Leicester, Leicester, UK
  3. 3Centre for Evaluation and Monitoring, University of Durham, UK
  4. 4National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK
  5. 5Academic Division of Neonatology, Institute for Women's Health, University College London, London, UK
  6. 6Great Ormond Street Hospital for Children and Institute of Child Health, University College London, London, UK
  1. Correspondence to Professor David R Jones, Health Sciences Department, Adrian Building (Room 214d), University of Leicester, University Road, Leicester LE1 7RH, UK; drj{at}le.ac.uk

Abstract

Objectives Statutory educational attainment measures are rarely used as health study outcomes, but Key Stage 1 (KS1) data formed secondary outcomes in the long-term follow-up to age 7 years of the ORACLE II trial of antibiotic use in preterm babies. This paper describes the approach, compares different approaches to analysis of the KS1 data and compares use of summary KS1 (level) data with use of individual question scores.

Participants 3394 children born to women in the ORACLE Children Study and resident in England at age 7.

Methods Analysis of educational achievement measured by national end of KS1 data (KS1) using Poisson regression modelling and anchoring of the KS1 data using external standards.

Results KS1 summary level data were obtained for 3239 (95%) eligible children; raw individual question scores were obtained for 1899 (54%). Use of individual question scores where available did not change the conclusion of no evidence of treatment effects based on summary KS1 outcome data.

Conclusions When accessible for medical research purposes, routinely collected educational outcome data may have advantages of low cost and standardised definition. Here, summary scores lead to similar conclusions to raw (individual question) scores and so are attractive and cost-effective alternatives.

https://doi.org/10.1136/adc.2010.184036

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    Footnotes

    • Funding Funded by UK Medical Research Council; sponsored by University Hospitals of Leicester. The sponsors had no role in the preparation of the manuscript or the decision to submit it.

    • Competing interests None.

    • Ethical approval OCS was approved by the West Midlands ethics committee in 2002.

    • Provenance and peer review Not commissioned; externally peer reviewed.