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Transient renal insufficiency following dipyrone overdose
  1. Ibrahim Abu-Kishk1,
  2. Michael Goldman2,
  3. Yair Mordish2,
  4. Matitiahu Berkovitch3,
  5. Eran Kozer4
  1. 1Pediatric Intensive Care Unit, Assaf Harofeh Medical Center, Zerifin, Israel
  2. 2Department of Pediatrics, Assaf Harofeh Medical Center, Zerifin, Israel
  3. 3Clinical Pharmacology and Toxicology Unit, Assaf Harofeh Medical Center, Zerifin, Israel
  4. 4Pediatric Emergency Unit, Assaf Harofeh Medical Center, Zerifin, Israel
  1. Correspondence to Matitiahu Berkovitch, Clinical Pharmacology and Toxicology Unit, Pediatric Division, Assaf Harofeh Medical Center, Zerifin 70300, Israel; mberkovitch{at}


Aim To describe the incidence of acute renal insufficiency after dipyrone overdose in children.

Methods The medical records of all patients ≤18 years of age during a 3-year period presenting at Assaf Harofeh Medical Center due to toxic exposure were retrospectively reviewed. Patients suffering from dipyrone overdose were compared with all the other patients.

Results 235 cases were included in the final analysis. Of these, 26 (11%) patients were exposed to dipyrone (median age 15 years). Three of the 26 patients (12%) had transient non-oliguric renal insufficiency. One other patient who did not receive dipyrone also developed transient renal insufficiency.

Conclusions Dipyrone overdose is frequent and may cause acute non-oliguric renal insufficiency. Renal function should be monitored in such patients.

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  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Assaf Harofeh Medical Center Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.