Article Text

Download PDFPDF

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

The survivors of heritable retinoblastoma have a very high risk of developing non-ocular tumours in later life. A cohort study in Great Britain (British Journal of Ophthalmology 2009;93: 1159–62) has included 1927 cases of retinoblastoma diagnosed between 1951 and 2004. Among these cases, 809 were considered to have the heritable form and 1118 the non-heritable. A non-ocular tumour developed in 102 (12.6%) and 13 (1.2%) of the heritable and nonheritable cases respectively. The cumulative risk for heritable cases was 10% after 25 years and 48% after 50 years. For non-heritable cases the corresponding ?gures were 0.7% and 5%. Among the 102 people with heritable retinoblastoma who developed non-ocular tumors there were 108 such tumours: 36 soft tissue sarcomas, 32 osteosarcomas, 13 carcinomas, 10 tumours of brain and central nervous system, 9 melanomas, 4 leukaemias, and 4 others.

Antipyretic drugs have been given to children at the time of routine vaccination in order to reduce the risk of a febrile reaction. Now a multicentre study in the Czech Republic (Lancet 2009;374:1339–50; see also Comment, ibid: 1305-6) has shown that paracetamol (acetaminophen) might interfere with …

View Full Text