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Worldwide burden of disease: Streptococcus pneumoniae and Haemophilus influenza type b in children less than 5 years old

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It has been estimated that, despite available preventive measures, Streptococcus pneumoniae kills up to a million children around the world each year, and Haemophilus influenzae type b up to 400 000. Much attention, research and funding has centred on HIV infection, malaria and tuberculosis, but country-specific estimates funded by the GAVI (Global Alliance for Vaccines and Immunisation) Alliance and the Vaccine Fund have now shown that child mortality from S pneumoniae and H influenzae type b infections is just as great (Katherine L O'Brien and colleagues. …

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