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Arterial wall thickness and blood pressure in children who were born small for gestational age: correlation with umbilical cord high-sensitivity C-reactive protein
  1. D Trevisanuto1,
  2. F Avezzù1,
  3. F Cavallin1,
  4. N Doglioni1,
  5. M Marzolo2,
  6. F Verlato2,
  7. V Zanardo1
  1. 1
    Department of Pediatrics, Medical School, University of Padua, Azienda Ospedaliera-Padova, Padua, Italy
  2. 2
    Department of Angiology Care Unit, Medical School, University of Padua, Azienda Ospedaliera-Padova, Padua, Italy
  1. Correspondence to Dr Daniele Trevisanuto, Pediatric Department, Medical School, University of Padua, Azienda Ospedaliera-Padova, Via Giustiniani, 3, 35128 Padua, Italy; trevo{at}


Background: Small for gestational age (SGA) infants have an increased risk of later cardiovascular disease. At birth, high sensitivity-C reactive protein (hs-CRP), a prognostic marker of cardiovascular disease, is significantly higher in SGA than in appropriate for gestational age (AGA) infants.

Aim: To measure aortic and carotid intima-media thickness (aIMT, cIMT) and blood pressure (BP) in children (aged 3–5 years) who were born SGA and AGA, and to assess the correlation between hs-CRP concentrations obtained at birth and these haemodynamic variables.

Methods: Umbilical cord hs-CRP concentrations were obtained in 38 neonates. In the same subjects aged 3–5 years, aIMT and cIMT were measured by high-resolution ultrasound scan, in the dorsal arterial wall. Anthropometric variables and BPs were obtained for each child.

Results: Maximum (median 0.700 mm, range 0.500–1.080 vs 0.650 mm, 0.400–0.860; p = 0.32) aIMTs were similar between children who were born SGA (n = 17) and AGA (n = 21), respectively. Concentrations of hs-CRP were not correlated with IMTs. In children who were born SGA, systolic BP was significantly correlated with umbilical cord hs-CRP concentrations (r = 0.60; p = 0.009).

Conclusions: Children who were born SGA have a higher, although not significant, aortic thickening than those who were born AGA. Umbilical cord hs-CRP concentrations do not seem to be involved in this process. Instead, hs-CRP concentrations were significantly related to systolic BP values in children who were born SGA, suggesting that hs-CRP at birth could be associated with sympathetic system hyperactivity and with the stress response during childhood.

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  • Competing interests None.

  • Provenance and Peer review Not commissioned; externally peer reviewed.

  • Ethics approval This study was approved by the research ethics committee of our hospital.

  • Patient consent Parental consent obtained.