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Prophylactic granulocyte-macrophage colony stimulating factor for small neonates: negative trial

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The haemopoietic colony stimulating factors, granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) increase neutrophil counts and, in theory, might reduce the risk of neonatal sepsis. They have been used prophylactically, but evidence of their effectiveness is inadequate. Now a trial at 26 UK centres (Robert Carr and colleagues. Lancet 2009;373:226–33; see also Comment, ibid: 188–90) has …

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