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Prospective follow-up oral food challenge in food protein-induced enterocolitis syndrome
  1. J-B Hwang1,
  2. S M Sohn1,
  3. A S Kim2
  1. 1
    Department of Pediatrics, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea
  2. 2
    Department of Pediatrics, Dongguk University College of Medicine, Gyeongju, Republic of Korea
  1. Dr Jin-Bok Hwang, Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Dongsan Medical Center, Keimyung University School of Medicine, 194 Dongsan-dong, Daegu, 700-712, Republic of Korea; pedgi{at}


Objectives: To determine tolerance rates to cow’s milk and soy and to suggest guidelines for follow-up oral food challenges (FU-OFCs) in infantile food protein-induced enterocolitis syndrome (FPIES).

Methods: The authors analysed the data of 23 patients with infantile FPIES who underwent two or more FU-OFCs and were followed up until over 2 years of age. The first FU-OFCs were performed at 6 months of age, and patients were randomly allocated to cow’s milk (n = 11) or soy (n = 12) challenge starting groups. Second and third FU-OFCs were performed at 2-month intervals in a crossed and switched-over manner.

Results: Tolerance rates to cow’s milk and soy were 27.3% and 75.0% at 6 months of age, 41.7% and 90.9% at 8 months and 63.6% and 91.7% at 10 months, respectively. Patients outgrew cow’s milk and soy intolerance at age 20 and 14 months.

Conclusions: In infantile FPIES, the first FU-OFC should be performed with soy at 6–8 months of age and cow’s milk FU-OFC should be conducted at over 12 months of age. Infants with FPIES were observed to outgrow food sensitivities during the first 2 years of life.

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  • Funding: None.

  • Competing interests: None.

  • Ethics approval: All study procedures were approved by the Keimyung University Institutional Review Board.