Article Text

Download PDFPDF
Rice: a common and severe cause of food protein-induced enterocolitis syndrome
  1. S S Mehr1,2,
  2. A M Kakakios1,
  3. A S Kemp1,2
  1. 1
    Department of Allergy and Immunology, The Children’s Hospital at Westmead, Sydney, Australia
  2. 2
    Disciplines of Paediatrics and Child Health, Clinical School, University of Sydney, Sydney, Australia
  1. Professor A Kemp, Department of Allergy and Immunology, The Children’s Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales 2145, Australia; andrewk5{at}


Objective: To examine and compare the characteristics of food protein-induced enterocolitis syndrome (FPIES) caused by rice and cow’s milk/soy.

Design: Retrospective study of children presenting with FPIES to the Children’s Hospital at Westmead, NSW, Australia, over a 16-year period.

Results: There were 14 children with 26 episodes of rice FPIES compared with 17 children with 30 episodes of cow’s milk (n = 10) or soy (n = 7) FPIES. Children with rice FPIES were more likely to have FPIES caused by other foods (36%) than children with FPIES caused by cow’s milk/soy (0%). Rice caused more episodes of FPIES before a correct diagnosis was made (median 4 (range 1–4) vs median 2 (range 1–4)) and triggered more severe reactions with higher rates of intravenous fluid resuscitation (42% vs 17%) than reactions caused by cow’s milk/soy.

Conclusions: This study highlights the emerging importance of rice, a food commonly thought to be “hypoallergenic”, as a significant trigger of FPIES. Paediatricians should be aware that rice not only has the potential to cause FPIES, but that such reactions tend be more severe than those caused by cow’s milk/soy.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding: SM was supported by funds received from the Australian Allergy Foundation.

  • Competing interests: None.

  • Ethics approval: Obtained.