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Lipoprotein(a) in healthy Welsh schoolchildren aged 12–13 years
  1. N E Thomas1,
  2. B Davies2,
  3. J S Baker3
  1. 1
    Centre for Child Research, Swansea University, Swansea, Wales, UK
  2. 2
    Division of Health and Science, University of Glamorgan, Pontypridd, Wales, UK
  3. 3
    Division of Sport and Exercise, University of the West of Scotland, Paisley, Scotland, UK
  1. Correspondence to Non E Thomas, Centre for Child Research, School of Human Sciences, Swansea University, Singleton Park, Swansea, Wales SA2 8PP, UK; n.e.thomas{at}swansea.ac.uk

https://doi.org/10.1136/adc.2009.167742

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    Lipoprotein(a) (Lp(a)) is a distinctive cholesterol-rich lipoprotein complex in blood. Population studies show that Lp(a) levels are not normally distributed but are skewed towards low concentrations of <10 mg/dl−1.1 Only 20% of Caucasians are thought to have levels >30 mg/dl−1, the threshold level nominated for cardiovascular disease (CVD) risk in both children and adults.1 Although Lp(a) takes the form of an independent risk factor,1 it is the combined elevated levels of Lp(a) and low-density lipoprotein cholesterol (LDL-C), or Lp(a) and fibrinogen (Fg) that is thought to have the greatest detrimental effect.2 3

    We determined the Lp(a) concentrations in schoolchildren aged 12–13 years in South Wales, as well as the percentage of children exhibiting …

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    Footnotes

    • Competing interests None.

    • Ethics approval The study’s protocol was approved by the University of Glamorgan's Ethics Committee.

    • Patient consent Parental consent obtained.

    • Contributors All authors contributed to the design, analysis and writing up of the paper.

    • Provenance and peer review Not commissioned; externally peer reviewed.