Article Text

  1. B Vasiljevic1,
  2. O Antonovic1,
  3. M Gojnic2
  1. 1Department of Neonatology, Institute of Gynecology and Obsterics, Clinical Centre of Serbia, Belgrade, Serbia
  2. 2Department of Gynecology, Institute of Gynecology and Obsterics, Clinical Centre of Serbia, Belgrade, Serbia


Objective The use of colour Doppler imaging allowing simultaneous examination of parenchymal and vascular cerebral structures. The evaluation of blood flow velocities in cerebral arteries is important in the assessment of cerebral circulation in hypoxicischaemic–haemorrhagic damage. The aim of this study is to estimate normal values of cerebral blood flow velocities (CBFV) and Doppler indices (PI and RI) in cerebral arteries (ACA) during the first 3 weeks of life in preterm infants.

Methods CBFV, PI and RI were obtained at 1, 3, 7, 14 and 21 days of life with colour Doppler technique in 50 preterm infants divided into three groups of gestational age ⩽28; 29–32; 33–36 weeks. Preterm infants with congenital malformations, cerebral haemorrhagic lesions, diastolic arterial pressure or hypotension were excluded.

Results The mean gestational age of infants was 32.5 ± 3.5 weeks (range 25–36) and mean body weight was 1540 ± 950 g (range 750–2800). In the first group of 10 infants, ⩽28 weeks the body weight was 950 ± 110 g and RI–ACA was 0.75 ± 0.13 and PI–ACA was 1.56 ± 0.34. In the second group of 20 infants, 29–32 weeks the body weight was 1350 ± 290 g and RI–ACA was 0.80 ± 0.12 and PI–ACA was 1.65 ± 0.35. In the thirrd group of 20 infants, 33–36 weeks the body weight was 1950 ± 750 g and RI–ACA was 0.85 ± 0.15 and PI–ACA was 1.65 ± 0.39.

Conclusions CBFV, RI and PI progressively increase with gestational age, body weight and postnatal age.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.