Article Text

  1. B Chevallier1,
  2. V Fournier2,
  3. E Lachambre3,
  4. B Logre4,
  5. F Ceccato5,
  6. L Beck3,
  7. G HuiBonHoa6,
  8. L D VanEgroo3
  1. 1Ambroise Pare Hospital, Boulogne Billancourt, France,
  2. 2Lyon, France,
  3. 3Laboratoires GUIGOZ, Noisiel, France,
  4. 4Floirac, France,
  5. 5Tresses, France,
  6. 6Cestas, France


Objective Uncomplicated gastro-oesophageal reflux is a frequent, aspecific phenomenon in infants (between 20 and 50% of infants are concerned). The recommended approach consists of reassurance of the parents and dietary recommendations in formula-fed infants. We previously showed in infants who spit up a rapid and lasting symptom improvement in decreasing of 50% the frequency of regurgitations from the 3 first days of using a new starch-thickened formula (chevallier et al, arch ped, 2007). The aim of this present study was to follow these infants up to the age of one year and to assess the evolution and management of symptoms.

Materials and Methods Infants under 3 months of age who presented regurgitations were first enrolled in an open study and received an antiregurgitation infant formula thickened with starch (2 g/100 ml) and containing structured lipids during 30 consecutive days. We performed a prospective follow-up study evaluating the evolution and management of regurgitations up to the age of one year.

Results 52 infants completed the follow-up study. They all received complementary foods from the age of 5.51 (+/−0.69) months. During follow-up, 8 infants received drug treatment without complementary investigations. Only 4 infants still spit up at one year, whose two presented with a grade of severity of regurgitations (according to scoring system invandenplas et al, eur j pediatr, 1994) of 2 and two a grade of 1.

Conclusion This first observational study confirms the possible persistence of regurgitation symptoms in some infants at one year of age, without pathologic gastro-oesophageal reflux diagnosis.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.