Background BPD is defined by need for oxygen and chest X ray abnormality at 36 weeks postmenstrual age and is associated with prolonged hospital stay, poor growth and increased risk for neurodevelopmental delay.
Objective To determine early risk factors for developing BPD or death.
Methods Retrospective review and data collection from clinical charts of all preterm infants admitted, before 12 hours of life, to our level 3 NICU between January 1st, 2003 and December 31st, 2006, born before 29 weeks without congenital defect. Risk factors significantly associated with BPD in univariate logistic regression (p-value<0.1) were introduced in multivariate regression. A forward stepwise was performed including respiratory variables, then successively general health variables, pregnancy variables, and finally age at delivery and gender.
Results Among the 302 subjects (mean ± SD; 26.6±1.3 weeks, 897±217 g) who meet inclusion criteria, 187 (62%) were free of BPD at 36 weeks. PROM, choriamnionitis, antenatal steroids, C section, age at ventilatory support, outborn status, age at admission, PDA at 28 days were not significant in univariate analysis. Multivariate analysis results are depicted in table.
Conclusions Early lung trauma, gender and immaturity are the main determinants of BPD among very preterm infants.
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